Oxygen Barrier Stability of Coated Vial after Mechanical Load

Polymeric materials such as cyclic olefin polymers (COP) may be used for parenteral drug packaging because they possess high optical clarity, high strength and impact resistance, low extractables, dimensional consistency, and a moisture vapor barrier. The robust mechanical properties of COP provide an impact and shatter-resistant container that can tolerate severe handling without failure. While the polymer matrix is robust there is concern that the thin oxygen barrier film will yield and not protect the interior of the vial from oxygen ingress. Technical Bulletin Series 2020-003